Data
Official data in SubjectManager for the following academic year: 2023-2024
Course director
-
Dr. Judit Erzsébet PONGRÁCZ
professor,
Department of Pharmaceutical Biotechnology -
Number of hours/semester
lectures: 14 hours
practices: 28 hours
seminars: 14 hours
total of: 56 hours
Subject data
- Code of subject: OTV-GGM2-T
- 7 kredit
- Biotechnology BSc
- Specialised Core Module modul
- spring
OTV-BIC2-T completed , OTV-GGM1-T completed
Course headcount limitations
min. 5 – max. 50
Topic
The subject expands on the knowledge which was accumulated in the previous semester. Gene mutation, DNA repair mechanisms and transposition, regulation of gene expression, transcriptional and post-transcriptional regulation will be discussed. Finally, epigenetic regulation of gene expression and its consequences will be the final topic.
Lectures
- 1. Gene mutations - Dr. Pongrácz Judit Erzsébet
- 2. Replication errors and Base modifications - Dr. Pongrácz Judit Erzsébet
- 3. Induced mutations induced by chemicals and radiation I. - Dr. Pongrácz Judit Erzsébet
- 4. Induced mutations induced by chemicals and radiation II. - Dr. Pongrácz Judit Erzsébet
- 5. Mutations in the background of human diseases I. - Dr. Pongrácz Judit Erzsébet
- 6. Mutations in the background of human diseases II. - Dr. Pongrácz Judit Erzsébet
- 7. Transposable elements - Dr. Pongrácz Judit Erzsébet
- 8. Regulation of gene expression in bacteria - Dr. Pongrácz Judit Erzsébet
- 9. Regulation of gene expression in Eukaryotes - Dr. Pongrácz Judit Erzsébet
- 10. Transcriptional regulation in Eukaryotes - Dr. Pongrácz Judit Erzsébet
- 11. The epigenome - Dr. Pongrácz Judit Erzsébet
- 12. Regulation of the epigenome - Dr. Pongrácz Judit Erzsébet
- 13. Epigenetics and diseases - Dr. Pongrácz Judit Erzsébet
- 14. Epigenetic traits - Dr. Pongrácz Judit Erzsébet
Practices
- 1. Sequence alignments
- 2. Sequence alignments
- 3. Sequence alignments
- 4. Sequence alignments
- 5. The effect of UV irradiation on cellular morphology and function
- 6. The effect of UV irradiation on cellular morphology and function
- 7. The effect of UV irradiation on cellular morphology and function
- 8. The effect of UV irradiation on cellular morphology and function
- 9. The effect of UV irradiation on gene expression
- 10. The effect of UV irradiation on gene expression
- 11. The effect of UV irradiation on gene expression
- 12. The effect of UV irradiation on gene expression
- 13. BLASTS - bioinformatics
- 14. BLASTS - bioinformatics
- 15. BLASTS - bioinformatics
- 16. BLASTS - bioinformatics
- 17. Designing disease models - Chromosomal modification - Downsyndrome mouse model
- 18. Designing disease models - Chromosomal modification - Downsyndrome mouse model
- 19. Designing disease models - Chromosomal modification - Downsyndrome mouse model
- 20. Designing disease models - Chromosomal modification - Downsyndrome mouse model
- 21. Designing disease models - transposons
- 22. Designing disease models - transposons
- 23. Designing disease models - transposons
- 24. Designing disease models - transposons
- 25. Swiss prot - protein sequences in disease analysis
- 26. Swiss prot - protein sequences in disease analysis
- 27. Swiss prot - protein sequences in disease analysis
- 28. Swiss prot - protein sequences in disease analysis
Seminars
- 1. Replication errors and Base modifications
- 2. Replication errors and Base modifications
- 3. Induced mutations induced by chemicals
- 4. Induced mutations induced by radiation
- 5. Mutations in the background of human diseases case study I.
- 6. Mutations in the background of human diseases case study II.
- 7. Mutations in the background of human diseases case study III.
- 8. Comparison of gene expression regulation in bacteria and humans I.
- 9. Comparison of gene expression regulation in bacteria and humans II.
- 10. Comparison of gene expression regulation in bacteria and humans III.
- 11. Comparison of gene expression regulation in bacteria and humans IV.
- 12. Epigenetics in the background of human diseases case study I.
- 13. Epigenetics in the background of human diseases case study II.
- 14. Epigenetics in the background of human diseases case study III.
Reading material
Obligatory literature
Literature developed by the Department
Own ppt, interactive teaching material
Notes
Recommended literature
Klug et al: Concepts of Genetics 12th Edition
Pierce: Genetics - A Conceptual Approach 7th Edition (2020)
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One midterm test, that can be repeated two more times if necessary.
Making up for missed classes
None
Exam topics/questions
Teams, Neptun, Departmental website
Examiners
- Dr. Pongrácz Judit Erzsébet
- Garai Kitti
Instructor / tutor of practices and seminars
- Ádám Zoltán Mihály
- Garai Kitti