Farmakológiai és Farmakoterápiai Intézet

Farmakológia és Farmakoterápiai Intézet cikkei 2013 – 2019.06.30.

 

2019

Bálint M, Horváth I, Mészáros N, Hetényi C: Towards Unraveling the Histone Code by Fragment Blind Docking.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20: Paper 422. 15 p. 2019.

 

Bátai IZ, Sár C Pápainé, Horváth Á, Kemény Á, Sándor Z, Nemes B, Helyes Z, Perkecz A, Mócsai A, Pozsgai G, Pintér E: TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis.

FRONTIERS IN PHARMACOLOGY: 10 Paper 964. 15 p. 2019.

 

Berekméri E, Deák O, Téglás T, Sághy É, Horváth T, Aller M, Fekete Á, Köles L, Zelles T: Targeted single-cell electroporation loading of Ca2+ indicators in the mature hemicochlea preparation.

HEARING RESEARCH 371: 75-86, 2019.

 

Csekő K, Beckers B, Keszthelyi D, Helyes Z: Role of TRPV1 and TRPA1 Ion Channels in Inflammatory Bowel Diseases : Potential Therapeutic Targets?.

PHARMACEUTICALS 12: Paper 48. 19 p. 2019.

 

Deres L, Eros K, Horvath O, Bencze N, Cseko C, Farkas S, Habon T, Toth K, Halmosi R: The Effects of Bradykinin B1 Receptor Antagonism on the Myocardial and Vascular Consequences of Hypertension in SHR Rats.

FRONTIERS IN PHYSIOLOGY 10: Paper 624. 14 p. 2019.

 

Faisal Z, Vörös V, Derdák D, Kunsági-Máté S, Bálint M, Hetényi C, Csepregi R, Kőszegi T, Bergmann D, Sueck F, Humpf HU, Hübner F, Poór M: Interaction of the mycotoxin metabolite dihydrocitrinone with serum albumin.

MYCOTOXIN RESEARCH 35: 129-139, 2019.

 

Fliszár-Nyúl E, Lemli B, Kunsági-Máté S, Dellafiora L, Dall’Asta Chiara, Cruciani Gabriele, Pethő G, Poór M: Interaction of Mycotoxin Alternariol with Serum Albumin

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20: Paper 2352. 18 p. 2019.

 

Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N, Ábrahám H, Pinteaux E, Francis S, Sensi S, Dénes Á, Goebel A: Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116: 13067-13076, 2019.

 

Horvath A, Botz B, Kiss T, Cseko K, Kiss I, Felinger A, Szabados T, Kenyeres E, Bencsik P, Mocsai A, Ferdinandy P, Helyes Z: Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?

FRONTIERS IN PHARMACOLOGY 10 Paper 233. 15 p. 2019.

 

Horváth I, Jeszenői N, Bálint M, Paragi G, Hetényi C: A Fragmenting Protocol with Explicit Hydration for Calculation of Binding Enthalpies of Target-Ligand Complexes at a Quantum Mechanical Level.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20: Paper 4384. 19 p. 2019.

 

Horváth S, Komlódi R, Perkecz A, Pintér E, Gyulai R, Kemény Á: Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice.

SCIENTIFIC REPORTS 9: Paper 3685. 8 p. 2019.

 

Hunyady Á, Hajna Z, Gubányi T, Scheich B, Kemény Á, Gaszner B, Borbély É, Helyes Z: Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms.

BRAIN RESEARCH BULLETIN 147: 165-173, 2019.

 

Kameda T, Zvick J, Vuk M, Sadowska A, Tam WK, Leung VY, Bölcskei K, Helyes Z, Applegate LA, Hausmann ON, Klasen J, Krupkova O, Wuertz-Kozak K: Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc : Association with Inflammation and Matrix Remodeling.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20: Paper 1767. 23 p. 2019.

 

Kellermayer Z, Vojkovics D, Dakah TA, Bodó K, Botz B, Helyes Z, Berta G, Kajtár B, Schippers A, Wagner N, Scotto L, O'Connor OA, Arnold HH, Balogh P: IL-22-Independent Protection from Colitis in the Absence of Nkx2.3 Transcription Factor in Mice.

JOURNAL OF IMMUNOLOGY 202: 1833-1844, 2019.

 

Kugyelka R, Prenek L, Olasz K, Kohl Z, Botz B, Glant TT, Berki T, Boldizsár F: ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis.

CELLS 8: Paper 504. 19 p. 2019.

 

Lázár B, Brenner GB, Makkos A, Balogh M, László S, Al-Khrasani M, Hutka B, Bató E, Ostorházi E, Juhász J, Kemény Á, László T, Tiszlavicz L, Bihari Z, Giricz Z, Szabó D, Helyes Z, Ferdinandy P, Gyires K, Zádori ZS: Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat.

CELLS 8: Paper 251. 17 p. 2019.

 

Matak I, Bölcskei K, Bach-Rojecky L, Helyes Z: Mechanisms of Botulinum Toxin Type A Action on Pain.

TOXINS: 11: Paper 459. 24 p. 2019.

 

Mohos V, Pánovics A, Fliszár-Nyúl E, Schilli G, Hetényi C, Mladěnka P, Needs PW, Kroon PA, Pethő G, Poór M: Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20: Paper 2681. 16 p. 2019.

 

Pethő G: A nem-szteroid gyulladásgátlók ciklooxigenáz-izoenzim-szelektivitásának mérése és jelentősége.

GYÓGYSZERÉSZET 63: 387-395, 2019.

 

Pozsgai G, Bátai IZ, Pintér E: Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 receptors.

BRITISH JOURNAL OF PHARMACOLOGY 176: 628-645, 2019.

 

Sandor Z, Bencsik T, Dekany A, Bartho L: Effects of Cinnamaldehyde on Smooth Muscle Preparations.

PHARMACOLOGY 104: 207-211, 2019.

 

Siekierska A, Stamberger H, Deconinck T, Oprescu SN, Partoens M, Zhang Y, Sourbron J, Adriaenssens E, Mullen P, Wiencek P, Hardies K, Lee JS, Giong HK, Distelmaier F, Elpeleg O, Helbig KL, Hersh J, Isikay S, Jordan E, Karaca E, Kecskes A, Lupski JR, Kovacs-Nagy R, May P, Narayanan V, Pendziwiat M, Ramsey K, Rangasamy S, Shinde DN, Spiegel R, Timmerman V, von Spiczak S, Helbig I, C4RCD Research Group, AR working group of the EuroEPINOMICS RES Consortium, Weckhuysen S, Francklyn C, Antonellis A, de Witte P, De Jonghe P: Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish.

NATURE COMMUNICATIONS 10: Paper 708. 15 p. 2019.

 

Szentes N, Tékus V, Mohos V, Borbély É, Helyes Z: Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex.

GEROSCIENCE 2019. doi: 10.1007/s11357-019-00059-1.

 

Vass Reka A, Kemeny A, Dergez T, Ertl T, Reglodi D, Jungling A, Tamas A: Distribution of bioactive factors in human milk samples.

INTERNATIONAL BREASTFEEDING JOURNAL 14: Paper 9. 10 p. 2019.

 

Vas V, Kovács T, Körmendi S, Bródy A, Kudlik G, Szeder B, Mező D, Kállai D, Koprivanacz K, Merő BL, Dülk M, Tóvári J, Vajdovich P, Şenel ŞN, Özcan I, Helyes Z, Dobó-Nagy C, Buday L: Significance of the Tks4 scaffold protein in bone tissue homeostasis.

SCIENTIFIC REPORTS 9: Paper 5781. 10 p. 2019.

 

 

2018

Almasi A, Pinto EDLN, Kovacs NP, Fischer T, Markovics Z, Fischer E, Perjesi P: Changes in hepatic metabolic enzyme activities and biliary excretion of 4-nitrophenol in streptozotocin induced diabetic rats.

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES 54: Paper e17347. 9 p. 2018.

 

Aczel T, Kun J, Szoke E, Rauch T, Junttila S, Gyenesei A, Bolcskei K, Helyes Z: Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model.

FRONTIERS IN MOLECULAR NEUROSCIENCE 11: Paper 219. 14 p. 2018.

 

Bán Á, Pintér E, Kun J: A megfelelő szájegészség megvédhet a kalciumcsatorna-blokkoló készítmények okozta gingivahyperplasia kialakulásától.

ORVOSI HETILAP 159: 1183-1187, 2018.

 

Bartho L, Sándor Z, Bencsik T: Effects of the venom of the brown bullhead catfish (Ameiurus nebulosus) on isolated smooth muscles.

ACTA BIOLOGICA HUNGARICA 69: 135-143, 2018.

 

Bátai IZ, Horváth Á, Pintér E, Helyes Z, Pozsgai G: Role of transient receptor potential ankyrin 1 ion channel and somatostatin sst4 receptor in the antinociceptive and anti-inflammatory effects of sodium polysulfide and dimethyl trisulfide.

FRONTIERS IN ENDOCRINOLOGY 9: Paper 55. 12 p. 2018.

 

Borbély É, Kiss T, Szabadfi K, Pintér E, Szolcsányi J, Helyes Z, Botz B: Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.

SCIENTIFIC REPORTS 8: Paper 15916. 8 p. 2018.

 

Bölcskei K, Kriszta G, Sághy É, Payrits M, Sipos É, Vranesics A, Berente Z, Ábrahám H, Ács P, Komoly S, Pintér E: Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice.

JOURNAL OF NEUROIMMUNOLOGY 320: 1-10, 2018.

 

Faisal Z, Lemli B, Szerencsés D, Kunsági-Máté S, Bálint M, Hetényi C, Kuzma M, Mayer M, Poór M: Interactions of zearalenone and its reduced metabolites α-zearalenol and β-zearalenol with serum albumins: species differences, binding sites, and thermodynamics.

MYCOTOXIN RESEARCH 34: 269-278, 2018.

 

Faisal Z, Derdák D, Lemli B, Kunsági-Máté S, Bálint M, Hetényi C, Csepregi R, Kőszegi T, Sueck F, Cramer B, Humpf HU, Poór M: Interaction of 2'R-ochratoxin A with Serum Albumins : Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells.

TOXINS 10: Paper 353. 16 p. 2018.

 

Feller D, Kun J, Ruzsics I, Rapp J, Sarosi V, Kvell K, Helyes Z, Pongracz JE: Cigarette smoke-induced pulmonary inflammation becomes systemic by circulating extracellular vesicles containing Wnt5a and inflammatory cytokines.

FRONTIERS IN IMMUNOLOGY 9: Paper 1724. 14 p. 2018.

 

Garami A, Pakai E, McDonald HA, Reilly RM, Gomtsyan A, Corrigan JJ, Pinter E, Zhu DXD, Lehto SG, Gavva NR, Kym PR, Romanovsky AA: TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds' pharmacological profiles, in-vivo targets, thermoeffectors recruited, and implications for drug development.

ACTA PHYSIOLOGICA 223: Paper e13038. 18 p. 2018.

 

Gulyas G, Pohoczky K, Csosz E, Simon A, Javor A, Czegledi L: Comparative proteome analysis of skeletal muscle between Merino and Tsigai lambs.

SMALL RUMINANT RESEARCH 158: 35-41, 2018.

 

Horváth Á, Borbély É, Bölcskei K, Szentes N, Kiss T, Belák M, Rauch T, Glant T, Zákány R, Juhász T, Karanyicz E, Boldizsár F, Helyes Z, Botz B. Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.

JOURNAL OF NEUROINFLAMMATION 15: Paper 335. 12 p. 2018.

 

Horvath A, Tekus V, Bencze N, Szentes N, Scheich B, Bolcskei K, Szoke E, Mocsai A, Toth-Sarudy E, Matyus P, Pinter E, Helyes Z: Analgesic effects of the novel semicarbazide-sensitive amine oxidase inhibitor SZV 1287 in mouse pain models with neuropathic mechanisms: involvement of transient receptor potential vanilloid 1 and ankyrin 1 receptors.

PHARMACOLOGICAL RESEARCH 131: 231-243, 2018.

 

Jeszenői N, Schilli N, Bálint M, Horváth I, Hetényi C: Analysis of the influence of simulation parameters on biomolecule-linked water networks.

JOURNAL OF MOLECULAR GRAPHICS AND MODELLING 82: 117-128, 2018.

 

Jozsa G, Szegeczki V, Palfi A, Kiss T, Helyes Z, Fülöp B, Cserhati C, Daróczi L, Tamás A, Zákány R, Reglődi D, Juhász T: Signalling Alterations in Bones of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Gene Deficient Mice.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19: Paper 2538. 23 p. 2018.

 

Kemény A, Kodji X, Horváth Sz, Komlódi R, Szőke E, Sándor Z, Perkecz A, Gyömörei Cs, Sétáló Gy, Kelemen B, Bíró T, Tóth B I, Brain S D, Pintér E, Gyulai R: TRPA1 acts in a protective manner in imiquimod-induced psoriasiform dermatitis in mice.

JOURNAL OF INVESTIGATIVE DERMATOLOGY 138: 1774-1784, 2018.

 

Kiraly K, Kozsurek M, Lukacsi E, Barta B, Alpar A, Balazsa T, Fekete C, Szabon J, Helyes Z, Bolcskei K, Tekus V, Toth ZE, Pap K, Gerber G, Puskar Z: Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain.

SCIENTIFIC REPORTS 8: Paper 3490. 15 p. 2018.

 

Kortesi T, Tuka B, Tajti J, Bagoly T, Fulop F, Helyes Z, Vecsei L: Kynurenic Acid Inhibits the Electrical Stimulation Induced Elevated Pituitary Adenylate Cyclase-Activating Polypeptide Expression in the TNC.

FRONTIERS IN NEUROLOGY 8: Paper 745. 8 p. 2018.

 

Kustro T, Kiss T, Chernohorskyi D, Chepurnyi Y, Helyes Z, Kopchak A: Quantification of the mandibular defect healing by micro CT morphometric analysis in rats.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 46: 2203-2213, 2018.

 

Mohacsik P, Erdelyi F, Baranyi M, Botz B, Szabo G, Toth M, Haltrich I, Helyes Z, Sperlagh B, Toth Z, Sinko R, Lechan RM, Bianco AC, Fekete C, Gereben B: A transgenic mouse model for detection of tissue-specific thyroid hormone action.

ENDOCRINOLOGY 159: 1159-1171, 2018.

 

Mohos V, Fliszár-Nyúl E, Schilli G, Hetényi C, Lemli B, Kunsági-Máté S, Bognár B, Poór M: Interaction of Chrysin and Its Main Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide with Serum Albumin.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19: Paper 4073. 15 p. 2018.

 

Mosdosi B, Bolcskei K, Helyes Z: Impairment of microcirculation and vascular responsiveness in adolescents with primary Raynaud phenomenon.

PEDIATRIC RHEUMATOLOGY 16: Paper 20. 8 p. 2018.

 

Nagy CT, Koncsos G, Varga ZV, Baranyai T, Tuza S, Kassai F, Ernyey AJ, Gyertyan I, Kiraly K, Olah A, Radovits T, Merkely B, Bukosza N, Szenasi G, Hamar P, Mathe D, Szigeti K, Pelyhe C, Jelemensky M, Onodi Z, Helyes Z, Schulz R, Giricz Z, Ferdinandy P: Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats.

BRITISH JOURNAL OF PHARMACOLOGY 175: 3713-3726, 2018.

 

Pakai E, Tekus V, Zsiboras C, Rumbus Z, Olah E, Keringer P, Khidhir N, Matics R, Deres L, Ordog K, Szentes N, Pohoczky K, Kemeny A, Hegyi P, Pinter E, Garami A: The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice.

FRONTIERS IN IMMUNOLOGY 9: Paper 166. 15 p. 2018.

 

Poór M, Boda G, Mohos V, Kuzma M, Bálint M, Hetényi C, Bencsik T: Pharmacokinetic interaction of diosmetin and silibinin with other drugs: Inhibition of CYP2C9-mediated biotransformation and displacement from serum albumin

BIOMEDICINE & PHARMACOTHERAPY 102: 912-921, 2018.

 

Rusznák K, Csekő K, Varga Z, Csabai D, Bóna Á, Mayer M, Kozma Z, Helyes Z, Czéh B: Long-Term Stress and Concomitant Marijuana Smoke Exposure Affect Physiology, Behavior and Adult Hippocampal Neurogenesis.

FRONTIERS IN PHARMACOLOGY 9: Paper 786. 20 p. 2018.

 

Saghy E, Payrits M, Biro-Suto T, Skoda-Foldes R, Szanti-Pinter E, Erostyak J, Makkai G, Setalo G Jr, Kollar L, Koszegi T, Csepregi R, Szolcsanyi J, Helyes Z, Szoke E: Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by lipid raft modulation.

JOURNAL OF LIPID RESEARCH 59: 1851-1863, 2018.

 

Sándor Z, Mottaghipisheh J, Veres K, Hohmann J, Bencsik T, Horváth A, Kelemen D, Papp R, Barthó L, Csupor D: Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles.

FRONTIERS IN PHARMACOLOGY 9: Paper 323. 11 p. 2018.

 

Schneider G, Szentes N, Horvath M, Dorn A, Cox A, Nagy G, Doffkay Z, Maroti G, Rakhely G, Kovacs T: Kinetics of Targeted Phage Rescue in a Mouse Model of Systemic Escherichia coli K1.

BIOMED RESEARCH INTERNATIONAL 2018: Paper 7569645. 8 p. 2018.

 

Szarka N, Pabbidi MR, Amrein K, Czeiter E, Berta G, Pohoczky K, Helyes Z, Ungvari Z, Koller A, Buki A, Toth P: Traumatic brain injury impairs myogenic constriction of cerebral arteries: role of mitochondria-derived H2O2 and TRPV4-dependent activation of BKCa channels.

JOURNAL OF NEUROTRAUMA 35: 930-939, 2018.

 

Tekus E, Miko A, Furedi N, Rostas I, Tenk J, Kiss T, Szitter I, Balasko M, Helyes Z, Wilhelm M, Petervari E: Body fat of rats of different age-groups and nutritional states: assessment by micro-CT and skinfold thickness.

JOURNAL OF APPLIED PHYSIOLOGY 124: 268-275, 2018.

 

Tekus V, Borbely E, Kiss T, Perkecz A, Kemeny A, Horvath J, Kvarda A, Pinter E: Investigation of Lake Heviz Mineral Water Balneotherapy and Heviz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018: Paper 4816905. 15 p. 2018.

 

Toth E, Tornoczky T, Kneif J, Perkecz A, Katona K, Piski Z, Kemeny A, Gerlinger I, Szolcsanyi J, Kun J, Pinter E: Upregulation of extraneuronal TRPV1 expression in chronic rhinosinusitis with nasal polyps.

RHINOLOGY 56: 245-254, 2018.

 

Vereb D, Szabo N, Tuka B, Tajti J, Kiraly A, Farago P, Kocsis K, Toth E, Kincses B, Bagoly T, Helyes Z, Vecsei L, Kincses ZT: Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures.

NEUROLOGY 91: e1166-e1174, 2018.

 

 

 

2017

Bálint M, Jeszenői N, Horváth I, Ábrahám IM, Hetényi C: Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects.

SCIENTIFIC REPORTS 7: Paper 14847. 15 p. 2017.

 

Balint M, Jeszenoi N, Horvath I, van der Spoel D, Hetenyi C: Systematic exploration of multiple drug binding sites.

JOURNAL OF CHEMINFORMATICS 9: Paper 65. 12 p. 2017.

 

Beckers AB, Weerts ZZRM, Helyes Z, Masclee AAM, Keszthelyi D: Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS 46: 938-952, 2017.

 

Beko K, Kovanyi B, Goloncser F, Horvath G, Denes A, Kornyei Z, Botz B, Helyes Z, Muller CE, Sperlagh B: Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS 15: 1223-1235, 2017.

 

Bohonyi N, Pohoczky K, Szalontai B, Perkecz A, Kovacs K, Kajtar B, Orban L, Varga T, Szegedi S, Bodis J, Helyes Z, Koppan M: Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis.

MOLECULAR PAIN 13: Paper 1744806917705564. 13 p. 2017.

 

Borbely E, Hajna Z, Nabi L, Scheich B, Tekus V, Laszlo K, Ollmann T, Kormos V, Gaszner B, Karadi Z, Lenard L, Paige CJ, Quinn JP, Szolcsanyi J, Pinter E, Keeble J, Berger A, Helyes Z: Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice.

BRAIN BEHAVIOR AND IMMUNITY 59: 219-232, 2017.

 

Borbely E, Helyes Z: Role of hemokinin-1 in health and disease.

NEUROPEPTIDES 64: 9-17, 2017.

 

Botz B, Bolcskei K, Helyes Z: Challenges to develop novel anti-inflammatory and analgesic drugs.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY 9: Paper e1427. 30 p. 2017.

 

Ecsédi P, Kiss B, Gógl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vértessy B, Jeszenői N, Hetényi C, Schlosser G, Katona G, Nyitray L: Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.

STRUCTURE 25: 1195-1207, e5. 2017.

 

Feher A, Toth VE, Al-Khrasani M, Balogh M, Lazar B, Helyes Z, Gyires K, Zadori Z: Analysing the effect of I1 imidazoline receptor ligands on DSS-induced acute colitis in mice.

INFLAMMOPHARMACOLOGY 25: 107-118, 2017.

 

Filotás D, Bátai IZ, Pozsgai G, Nagy L, Pintér E, Nagy G: Highly sensitive potentiometric measuring method for measurement of free H2S in physiologic samples.

SENSORS AND ACTUATORS B-CHEMICAL 243: 326-331, 2017.

 

Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM: Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents.

ANESTHESIOLOGY 127: 813-823, 2017.

 

Helyes Z, Kemeny A, Cseko K, Szoke E, Elekes K, Mester M, Sandor K, Perkecz A, Kereskai L, Mark L, Bona A, Benko A, Pinter E, Szolcsanyi J, Ledent C, Sperlagh B, Molnar TF: Marijuana smoke induces severe pulmonary hyperresponsiveness, inflammation and emphysema in a predictive mouse model not via CB1 receptor activation.

AMERICAN JOURNAL OF PHYSIOLOGY: LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 313: L267-L277, 2017.

 

Horvath A, Menghis A, Botz B, Borbely E, Kemeny A, Tekus V, Csepregi JZ, Mocsai A, Juhasz T, Zakany R, Bogdan D, Matyus P, Keeble J, Pinter E, Helyes Z: Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.

SCIENTIFIC REPORTS 7: Paper 39863. 13 p. 2017.

 

Kemeny A, Cseko K, Szitter I, Varga ZV, Bencsik P, Kiss K, Halmosi R, Deres L, Eros K, Perkecz A, Kereskai L, Laszlo T, Kiss T, Ferdinandy P, Helyes Z: Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model.

ENVIRONMENTAL POLLUTION 229: 746-759, 2017.

 

Kun J, Perkecz A, Knie L, Setalo G Jr, Tornoczky T, Pinter E, Ban A:  TRPA1 receptor is upregulated in human oral lichen planus.

ORAL DISEASES 23: 189-198, 2017.

 

Matak I, Tekus V, Bolcskei K, Lackovic Z, Helyes Z: Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice.

NEUROSCIENCE 358: 137-145, 2017.

 

Mosdosi B, Nyul Z, Nagy A, Bolcskei K, Decsi T, Helyes Z: Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient.

CROATIAN MEDICAL JOURNAL 58: 424-430, 2017.

 

Payrits M, Sághy É, Csekő K, Pohóczky K, Bölcskei K, Ernszt D, Barabás K, Szolcsányi J, Ábrahám IM, Helyes Z, Szőke É: Estradiol sensitizes the Transient Receptor Potential Vanilloid 1 receptor in pain responses.

ENDOCRINOLOGY 158: 3249-3258, 2017.

 

Pethő G, Bölcskei K, Füredi R, Botz B, Bagoly T, Pintér E, Szolcsányi J: Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats.

NEUROPEPTIDES 62: 1-10. (2017)

 

Pinter E, Bolcskei K, Saghy E, Payrits M, Kriszta G, Vranesics A, Sipos E, Acs P, Berente Z, Abraham H, Komoly S: TRPA1 receptor deficiency substantially diminishes the cuprizone-induced demyelination.

JOURNAL OF NEUROCHEMISTRY 142: 171-172, 2017.

 

Poór M, Kunsági-Máté S, Bálint M, Hetényi C, Gerner Z, Beáta L: Interaction of mycotoxin zearalenone with human serum albumin.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 170: 16-24, 2017.

 

Poór M, Németi B, Gregus Z: Effects of phosphate binders on the gastrointestinal absorption of arsenate and of an SGLT2 inhibitor drug on the urinary excretion of arsenite in mice.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 49: 179-187, 2017.

 

Pozsgai G, Payrits M, Saghy E, Sebestyen-Batai R, Steen E, Szoke E, Sandor Z, Solymar M, Garami A, Orvos P, Talosi L, Helyes Z, Pinter E: Analgesic effect of dimethyl trisulfide in mice is mediated by TRPA1 and sst4 receptors.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 65: 10-21, 2017.

 

Rinsma NF, Farre R, Troost FJ, Elizalde M, Keszthelyi D, Helyes Z, Masclee AA, Conchillo JM: Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18: Paper 1091. 12 p. 2017.

 

Scheich B, Cseko K, Borbely E, Abraham I, Csernus V, Gaszner B, Helyes Z: Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations.

NEUROSCIENCE 346: 320-336, 2017.

 

Scheich B, Vincze P, Szoke E, Borbely E, Hunyady A, Szolcsanyi J, Denes A, Kornyei Z, Gaszner B, Helyes Z: Chronic stress-induced mechanical hyperalgesia is controlled by capsaicin-sensitive neurones in the mouse.

EUROPEAN JOURNAL OF PAIN 21: 1417-1431, 2017.

 

 

2016

Borbély É, Sándor K, Markovics A, Kemény Á, Pintér E, Szolcsányi J, Quinn JP, McDougall JJ, Helyes Z: Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.

INFLAMMATION RESEARCH 65: 725-736, 2016.

 

Botz B, Kemeny A, Brunner SM, Locker F, Csepregi J, Mocsai A, Pinter E, McDougall JJ, Kofler B, Helyes Z: Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis.

JOURNAL OF MOLECULAR NEUROSCIENCE 59: 260-269, 2016.

 

Botz B, Brunner SM, Kemeny A, Pinter E, McDougall JJ, Kofler B, Helyes Z: Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype.

EXPERIMENTAL DERMATOLOGY 25: 725-727, 2016.

Csabai D, Cseko K, Szaiff L, Varga Z, Miseta A, Helyes Z, Czeh B: Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice.

BEHAVIOURAL BRAIN RESEARCH 302: 44-52, 2016.

 

Farkas S, Bolcskei K, Markovics A, Varga A, Kis-Varga A, Kormos V, Gaszner B, Horvath C, Tuka B, Tajti J, Helyes Z: Utility of different outcome measures for the nitroglycerin model of migraine in mice.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 77: 33-44, 2016.

 

Hajna Z, Szabadfi K, Balla Z, Biro Z, Degrell P, Molnar GA, Koszegi T, Tekus V, Helyes Z, Dobos A, Farkas S, Szucs G, Gabriel R, Pinter E: Modeling long-term diabetes and related complications in rats.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 78: 1-12, 2016.

 

Hajna Z, Saghy E, Payrits M, Aubdool AA, Szoke E, Pozsgai G, Batai IZ, Nagy L, Filotas D, Helyes Z, Brain SD, Pinter E: Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release.

JOURNAL OF MOLECULAR NEUROSCIENCE 60: 157-170, 2016.

 

Horvath A, Tekus V, Boros M, Pozsgai G, Botz B, Borbely E, Szolcsanyi J, Pinter E, Helyes Z: Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice.

ARTHRITIS RESEARCH & THERAPY 18: Paper 6. 14 p. 2016.

 

Ivic I, Solymar M, Pakai E, Rumbus Z, Pinter E, Koller A, Garami A: Transient Receptor Potential Vanilloid-1 Channels Contribute to the Regulation of Acid- and Base-Induced Vasomotor Responses.

JOURNAL OF VASCULAR RESEARCH 53: 279-290, 2016.

 

Kemény Á, Horváth S, Komlódi R, Perkecz A, Gyömörei C, Pintér E, Gyulai R: The TRPA1 ion channel mediates inhibitory effects on imiquimod-induced psoriasiform skin inflammation.

JOURNAL OF INVESTIGATIVE DERMATOLOGY 36: S228. 1 p. 2016.

 

Koncsos G, Varga ZV, Baranyai T, Boengler K, Rohrbach S, Li L, Schluter KD, Schreckenberg R, Radovits T, Olah A, Matyas C, Lux A, Al-Khrasani M, Komlodi T, Bukosza N, Mathe D, Deres L, Bartekova M, Rajtik T, Adameova A, Szigeti K, Hamar P, Helyes Z, Tretter L, Pacher P, Merkely B, Giricz Z, Schulz R, Ferdinandy P: Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress.

AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY 311: H927-H943, 2016.

 

Kormos V, Gaspar L, Kovacs L, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglodi D, Helyes Z, Gaszner B: Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers.

NEUROSCIENCE 330: 335-358, 2016.

 

Lacko E, Riba P, Giricz Z, Varadi A, Cornic L, Balogh M, Kiraly K, Cseko K, Mousa SA, Hosztafi S, Schafer M, Zadori ZS, Helyes Z, Ferdinandy P, Furst S, Al-Khrasani M: New morphine analogues produce peripheral antinociception within a certain dose range of their systemic administration.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 359: 171-181, 2016.

 

Lackovic Z, Filipovic B, Matak I, Helyes Z: Botulinum toxin type A activity in cranial dura: implications for treatment of migraine and other headaches.

BRITISH JOURNAL OF PHARMACOLOGY 173: 279-291, 2016.

 

Muley MM, Reid AR, Botz B, Bolcskei K, Helyes Z, McDougall JJ: Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.

BRITISH JOURNAL OF PHARMACOLOGY 173: 766-777, 2016.

 

Payrits M, Sághy É, Mátyus P, Czompa A, Ludmerczki R, Demed R, Sándor Z, Helyes Zs, Szőke É: A novel 3-(4,5-Diphenyl-l,3-oxazol-2-yl)propanal oxime compound is a potent Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and V1) receptor antagonist.

NEUROSCIENCE 324: 151-162, 2016.

 

Pohoczky K, Kun J, Szalontai B, Szoke E, Saghy E, Payrits M, Kajtar B, Kovacs K, Kornyei JL, Garai J, Garami A, Perkecz A, Czegledi L, Helyes Z: Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium.

JOURNAL OF MOLECULAR ENDOCRINOLOGY 56: 135-149, 2016.

 

Saghy E, Sipos E, Acs P, Bolcskei K, Pohoczky K, Kemeny A, Sandor Z, Szoke E, Setalo G Jr, Komoly S, Pinter E: TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis.

GLIA 64: 2166-2180, 2016.

 

Sandor B, Fintor K, Reglodi D, Fulop DB, Helyes Z, Szanto I, Nagy P, Hashimoto H, Tamas A: Structural and Morphometric Comparison of Lower Incisors in PACAP-Deficient and Wild-Type Mice.

JOURNAL OF MOLECULAR NEUROSCIENCE 59: 300-308, 2016.

 

Sándor Z, Bencsik T, Dékány A, Bartho L: Serotonin or the Mucosa Do Not Mediate the Motor Effect of Allyl Isothiocyanate in the Guinea-Pig Small Intestine.

PHARMACOLOGY 98: 199-203, 2016.

 

Sándor Z, Dekany A, Kelemen D, Bencsik T, Papp R, Bartho L: The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 119: 341-342, 2016.

 

Scheich B, Gaszner B, Kormos V, Laszlo K, Adori C, Borbely E, Hajna Z, Tekus V, Bolcskei K, Abraham I, Pinter E, Szolcsanyi J, Helyes Z: Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.

NEUROPHARMACOLOGY 101: 204-215, 2016.

 

Tékus Valéria, Horváth Ádám, Hajna Zsófia, Borbély Éva, Bölcskei Kata, Boros Melinda, Pintér Erika, Helyes Zsuzsanna, Pethő Gábor, Szolcsányi János: Noxious heat threshold temperature and pronociceptive effects of allyl isothiocyanate (mustard oil) in TRPV1 or TRPA1 gene-deleted mice.

LIFE SCIENCES 154: 66-74, 2016.

 

Tuka B, Szabo N, Toth E, Kincses ZT, Pardutz A, Szok D, Kortesi T, Bagoly T, Helyes Z, Edvinsson L, Vecsei L, Tajti J: Release of PACAP-38 in episodic cluster headache patients - an exploratory study.

JOURNAL OF HEADACHE AND PAIN 17: Paper 69. 7 p. 2016.

 

van Avesaat M, Troost FJ, Westerterp-Plantenga MS, Helyes Z, Le Roux CW, Dekker J, Masclee AA, Keszthelyi D: Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones.

AMERICAN JOURNAL OF CLINICAL NUTRITION 103: 305-313, 2016.

 

Zadori ZS, Toth VE, Feher A, Al-Khrasani M, Puskar Z, Kozsurek M, Timar J, Tabi T, Helyes Z, Hein L, Holzer P, Gyires K: Inhibition of alpha2A-adrenoceptors ameliorates Dextran Sulfate Sodium-induced acute intestinal inflammation in mice.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 358: 483-491, 2016.

 

 

2015

Adori C, Gluck L, Barde S, Yoshitake T, Kovacs GG, Mulder J, Magloczky Z, Havas L, Bolcskei K, Mitsios N, Uhlen M, Szolcsanyi J, Kehr J, Ronnback A, Schwartz T, Rehfeld JF, Harkany T, Palkovits M, Schulz S, Hokfelt T: Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.

ACTA NEUROPATHOLOGICA 129: 541-563, 2015.

 

Banki E, Sosnowska D, Tucsek Zs, Gautami T, Toth P, Tarantini S, Tamas A, Helyes Zs, Reglodi D, Sonntag WE, Csiszar A, Ungvari Z: Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide (PACAP) impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 70: 665-674, 2015.

 

Bencsik T, Sándor Z, Barthó L: High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs.

PHARMACOLOGY 96: 86-89, 2015.

 

Benko R, Molnar TF, Szombati V, Benko I, Bartho L: Combined Inhibition of Histamine H-1 Receptors and Leukotrienes Reduces Compound 48/80-Induced Contraction of the Human Bronchus in vitro.

PHARMACOLOGY 96: 253-255, 2015.

 

Borbely E, Botz B, Bolcskei K, Kenyer T, Kereskai L, Kiss T, Szolcsanyi J, Pinter E, Csepregi JZ, Mocsai A, Helyes Z: Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis.

BRAIN BEHAVIOR AND IMMUNITY 45: 50-59, 2015.

 

Botz B, Bolcskei K, Kemeny A, Sandor Z, Tekus V, Setalo G Jr, Csepregi J, Mocsai A, Pinter E, Kollar L, Helyes Z: Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption.

JOURNAL OF BIOMEDICAL OPTICS 20: Paper 016022. 9 p. 2015.

 

Hajna Z, Borbely E, Kemeny A, Botz B, Kereskai L, Szolcsanyi J, Pinter E, Paige CJ, Berger A, Helyes Z: Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse.

PEPTIDES 64: 1-7, 2015.

 

Helyes Z, Kun J, Dobrosi N, Sándor K, Németh J, Perkecz A, Pintér E, Szabadfi K, Gaszner B, Tékus V, Szolcsányi J, Steinhoff M, Hashimoto H, Reglődi D, Bíró T: Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema.

JOURNAL OF INVESTIGATIVE DERMATOLOGY 135: 2209-2218, 2015.

 

Horváth G, Kemény Á, Barthó L, Molnár P, Deli J, Szente L, Bozó T, Pál S, Sándor K, Szőke É, Szolcsányi J, Helyes Z: Effects of some natural carotenoids on TRPA1- and TRPV1-induced neurogenic inflammatory processes in vivo in the mouse skin.

JOURNAL OF MOLECULAR NEUROSCIENCE 56: 113-121, 2015.

 

Nemeti B, Poor M, Gregus Z: Reduction of the Pentavalent Arsenical Dimethylarsinic Acid and the GSTO1 Substrate S-(4-Nitrophenacyl)glutathione by Rat Liver Cytosol: Analyzing the Role of GSTO1 in Arsenic Reduction.

CHEMICAL RESEARCH IN TOXICOLOGY 28: 2199-2209, 2015.

 

Poór M, Lemli B, Bálint M, Hetényi C, Sali N, Kőszegi T, Kunsági-Máté S: Interaction of citrinin with human serum albumin.

TOXINS 7: 5155-5166, 2015.

 

Pozsgai G, Benko R, Bartho L, Horvath K, Pinter E: Thermal spring water drinking attenuates dextran-sulfate-sodium-induced colitis in mice.

INFLAMMOPHARMACOLOGY 23: 57-64, 2015.

 

Saghy E, Payrits M, Helyes Z, Reglodi D, Banki E, Toth G, Couvineau A, Szoke E: Stimulatory effect of pituitary adenylate-cyclase activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons.

NEUROSCIENCE 308: 144-156, 2015.

 

Sághy É, Szőke É, Payrits M, Helyes Z, Börzsei R, Erostyák J, Jánosi TZ, Sétáló G Jr, Szolcsányi J: Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals.

PHARMACOLOGICAL RESEARCH 100: 101-116, 2015.

 

Szánti-Pintér E, Wouters J, Gömöry Á, Sághy É, Szőke É, Helyes Z, Kollár L, Skoda-Földes R: Synthesis of novel 13α-18-norandrostane-ferrocene conjugates via homogeneous catalytic methods and their investigation on TRPV1 receptor activation.

STEROIDS 104: 284-293, 2015.

 

Szlavicz E, Perera PS, Tomboly C, Helyes Z, Zador F, Benyhe S, Borsodi A, Bojnik E: Further Characterization of Hemopressin Peptide Fragments in the Opioid and Cannabinoid Systems.

ANESTHESIA AND ANALGESIA 121: 1488-1494, 2015.

 

Tajti J, Tuka B, Botz B, Helyes Z, Vécsei L: Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 14: 540-553, 2015.

 

Tóth B, Bartho L, Vasas A, Sándor Z, Jedlinszki N, Pinke G, Hohmann J: Dual Excitatory and Smooth Muscle-relaxing Effect of Sideritis montana Extract on Guinea-pig Ileum.

NATURAL PRODUCT COMMUNICATIONS 10: 487-490, 2015.

 

 

2014

Banki E, Hajna Z, Kemény Á, Botz B, Nagy P, Bölcskei K, Tóth G, Reglődi D, Helyes Z: The selective PAC1 receptor agonist maxadilan inhibits neurogenic vasodilation and edema formation in the mouse skin.

NEUROPHARMACOLOGY 85: 538-547, 2014.

 

Bartho L, Sándor Z, Kelemen D, Papp R, Benkó R: Smooth Muscle-Depressant Activity of AP-18, a Putative TRPA1 Antagonist in the Guinea Pig Intestine.

PHARMACOLOGY 94: 131-134, 2014.

 

Benyhe Z, Toth G, Wollemann M, Borsodi A, Helyes Z, Rougeot C, Benyhe S: Effects of synthetic analogues of human opiorphin on rat brain opioid receptors.

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 65: 525-530, 2014.

 

Botz B, Bölcskei K, Kereskai L, Kovács M, Németh T, Szigeti K, Horváth I, Máthé D, Kovács N, Hashimoto H, Reglődi D, Szolcsányi J, Pintér E, Mócsai A, Helyes Zs: Differential Regulatory Role of Pituitary Adenylate Cyclase–Activating Polypeptide in the Serum-Transfer Arthritis Model.

ARTHRITIS & RHEUMATOLOGY 66: 2739-2750, 2014.

 

Bukovics P, Czeiter E, Amrein K, Kovacs N, Pal J, Tamas A, Bagoly T, Helyes Z, Buki A, Reglodi D: Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury.

PEPTIDES 60: 18-22, 2014.

 

Feher J, Pinter E, Kovács I, Helyes Z, Kemény A, Markovics A, Plateroti R, Librando A, Cruciani F: Irritable Eye Syndrome: Neuroimmune Mechanisms and Benefits of Selected Nutrients.

OCULAR SURFACE 12: 134-145, 2014.

 

Horváth K, Boros M, Bagoly T, Sándor V, Kilár F, Kemény Á, Helyes Zs, Szolcsányi J, Pintér E: Analgesic topical capsaicinoid therapy increases somatostatin-like immunoreactivity in the human plasma.

NEUROPEPTIDES 48: 371-378, 2014.

 

Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A: The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

JOURNAL OF EXPERIMENTAL MEDICINE 211: 1993-2011, 2014.

 

Kun J, Szitter I, Kemeny A, Perkecz A, Kereskai L, Pohoczky K, Vincze A, Godi S, Szabo I, Szolcsanyi J, Pinter E, Helyes Z: Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles.

PLOS ONE 9: Paper e108164. 15 p. 2014.

 

Nagy L, Filotas D, Boros M, Pozsgai G, Pinter E, Nagy G: Amperometric cell for subcutaneous detection of hydrogen sulfide in anesthetized experimental animals.

PHYSIOLOGICAL MEASUREMENT 35: 2475-2487, 2014.

 

de Oliveira C, Garami A, Lehto SG, Pakai E, Tekus V, Pohoczky K, Youngblood BD, Wang W, Kort ME, Kym PR, Pinter E, Gavva NR, Romanovsky AA: Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.

JOURNAL OF NEUROSCIENCE 34: 4445-4452, 2014.

 

Pintér E, Pozsgai G, Hajna Z, Helyes Z, Szolcsányi J: Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 77: 5-20, 2014.

 

Suto B, Szitter I, Bagoly T, Pinter E, Szolcsányi J, Loibl Cs, Nemeth T, Tanczos K, Molnar T, Leiner T, Varnai B, Bardonicsek Z, Helyes Z: Plasma somatostatin-like immunoreactivity increases in the plasma of septic patients and rats with systemic inflammatory reaction: experimental evidence for its sensory origin and protective role.

PEPTIDES 54:  49-57, 2014.

 

Szabadfi K, Pintér E, Reglődi D, Gábriel R: Neuropeptides, trophic factors, and other substances providing morphofunctional and metabolic protection in experimental models of diabetic retinopathy.

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY 311: 1-121. 2014.

 

Szitter I, Pintér E, Perkecz A, Kemény Á, Kun J, Kereskai L, Pietra C, Quinn JP, Zimmer A, Berger A, Paige CJ, Helyes Z: Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant.

INFLAMMATION RESEARCH 63: 399-409, 2014.

 

Tekus V, Hajna Z, Borbely E, Markovics A, Bagoly T, Szolcsanyi J, Thompson V, Kemeny A, Helyes Z, Goebel A: A CRPS-IgG-Transfer-Trauma Model Reproducing Inflammatory and Positive Sensory Signs associated with Complex Regional Pain Syndrome.

PAIN 155: 299-308, 2014.

 

 

2013

Bartho L, Benko R: Should antihistamines be re-considered as antiasthmatic drugs as adjuvants to anti-leukotrienes?

EUROPEAN JOURNAL OF PHARMACOLOGY 701: 181-184, 2013.

 

Bartho L, Nordtveit E, Szombati V, Benko R: Purinoceptor-mediated, Capsaicin-resistant Excitatory Effect of Allyl Isothiocyanate on Neurons of the Guinea-Pig Small Intestine.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 113: 141-143, 2013.

 

Bencsik T, Barthó L, Sándor V, Papp N, Benkó R, Felinger A, Kilár F, Horváth G: Phytochemical evaluation of Lythrum salicaria L. extracts and their effects on guinea pig ileum.

NATURAL PRODUCT COMMUNICATIONS 8: 1247-1250, 2013.

 

Benko R, Szombati V, Bartho L: Evidence that Adrenergic and Cholinergic but Not Capsaicin-Sensitive Nerves Are Involved in the Nerve-Mediated Contraction of the Guinea Pig Seminal Vesicle.

PHARMACOLOGY 92: 39-42, 2013.

 

Borbely E, Hajna Z, Sandor K, Kereskai L, Toth I, Pinter E, Nagy P, Szolcsanyi J, Quinn J, Zimmer A, Stewart J, Paige C, Berger A, Helyes Z: Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.

PLOS ONE 8:(4) Paper e61684. 8 p. 2013.

 

Borbely E, Scheich B, Helyes Z: Neuropeptides in learning and memory.

NEUROPEPTIDES 47: 439-450,. 2013.

 

Boros M, Benkó R, Bölcskei K, Szolcsányi J, Barthó L, Pethő G: Effects of Reference Analgesics and Psychoactive Drugs on the Noxious Heat Threshold of Mice Measured by an Increasing-Temperature Water Bath.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 113: 385-390, 2013.

 

Boros M, Kemény A, Sebok B, Bagoly T, Perkecz A, Petoházi Z, Maász G, Schmidt J, Márk L, László T, Helyes Z, Szolcsányi J, Pintér E: Sulphurous medicinal waters increase somatostatin release: It is a possible mechanism of anti-inflammatory effect of balneotherapy in psoriasis.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE 5: 109-118, 2013.

 

Botz B, Imreh A, Sándor K, Elekes K, Szolcsányi J, Reglődi D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z: Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions.

PEPTIDES 43: 105-112, 2013.

 

Dekany A, Benko R, Szombati V, Bartho L: The Contractile Effect of Anandamide in the Guinea-Pig Small Intestine is Mediated by Prostanoids but not TRPV1 Receptors or Capsaicin-Sensitive Nerves.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 112: 341-345, 2013.

 

Keszthelyi D, Troost FJ, Jonkers DM, Helyes Z, Hamer HM, Ludidi S, Vanhoutvin S, Venema K, Dekker J, Szolcsányi J, Masclee AA: Alterations in mucosal neuropeptides in patients with irritable bowel syndrome and ulcerative colitis in remission: A role in pain symptom generation?

EUROPEAN JOURNAL OF PAIN 17: 1299-1306, 2013.

 

Németi B, Gregus Z: Reduction of dimethylarsinic acid to the highly toxic dimethylarsinous acid by rats and rat liver cytosol.

CHEMICAL RESEARCH IN TOXICOLOGY 26: 432-443, 2013.

 

Szabo IL, Czimmer J, Szolcsanyi J, Mozsik G: Molecular Pharmacological Approaches to Effects of Capsaicinoids and of Classical Antisecretory Drugs on Gastric Basal Acid Secretion and on Indomethacin-Induced Gastric Mucosal Damage in Human Healthy Subjects (Mini Review).

CURRENT PHARMACEUTICAL DESIGN 19: 84-89, 2013.

 

Szolcsányi J: Neuroregulation of cutaneous microcirculation: The shadow of Sir Thomas Lewis.

TRENDS IN PHARMACOLOGICAL SCIENCES 34: 591-592, 2013.

 

Szolcsányi J, Pintér E: Transient receptor potential vanilloid 1 as a therapeutic target in analgesia.

EXPERT OPINION ON THERAPEUTIC TARGETS 17: 641-657, 2013.

 

Tuka B, Helyes Z, Markovics A, Bagoly T, Szolcsányi J, Szabó N, Tóth E, Kincses Z T, Vécsei L, Tajti J: Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients.

CEPHALALGIA 33: 1085-1095, 2013.